Revolutionizing cancer treatment: enhancing CAR-T cell therapy with CRISPR/Cas9 gene editing technology

Revolutionizing cancer treatment: enhancing CAR-T cell therapy with CRISPR/Cas9 gene editing technology

Blog Article

CAR-T cell therapy, a novel immunotherapy, has made significant breakthroughs in clinical practice, particularly in treating B-cell-associated leukemia and lymphoma.However, it still faces challenges such as poor persistence, limited proliferation capacity, high manufacturing costs, and suboptimal efficacy.CRISPR/Cas system, an efficient and simple method for precise gene editing, kicker pro comp 10 offers new possibilities for optimizing CAR-T cells.It can increase the function of CAR-T cells and reduce manufacturing costs.

The combination of CRISPR/Cas9 technology and CAR-T cell therapy may promote the development of this therapy and provide more effective and personalized treatment for cancer patients.Meanwhile, the safety issues surrounding the application of this technology in CAR-T cells require further research and evaluation.Future research should focus on improving the click here accuracy and safety of CRISPR/Cas9 technology to facilitate the better development and application of CAR-T cell therapy.This review focuses on the application of CRISPR/Cas9 technology in CAR-T cell therapy, including eliminating the inhibitory effect of immune checkpoints, enhancing the ability of CAR-T cells to resist exhaustion, assisting in the construction of universal CAR-T cells, reducing the manufacturing costs of CAR-T cells, and the security problems faced.

The objective is to show the revolutionary role of CRISPR/Cas9 technology in CAR-T cell therapy for researchers.